Search results for "Hiv seropositive"

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Phenotypic Alteration of Neutrophils in the Blood of HIV Seropositive Patients

2013

We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease.

AdultCD4-Positive T-LymphocytesMaleNeutrophilsHiv seropositivePopulationlcsh:MedicineHIV InfectionsDiseaseCD13 AntigensBiologyPeripheral blood mononuclear cellFlow cytometryYoung Adult03 medical and health sciences0302 clinical medicinemedicineHumansYoung adultlcsh:ScienceeducationSpecific Gravity030304 developmental biology0303 health scienceseducation.field_of_studyMultidisciplinaryArginasemedicine.diagnostic_testlcsh:RMiddle AgedViral LoadVirologyPhenotypeCD4 Lymphocyte Count3. Good healthPhenotypeImmunologyHIV-1lcsh:QFemaleViral loadBiomarkersResearch Article030215 immunologyPLoS ONE
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Serum malondialdehyde in HIV-seropositive children negatively correlates with CD4+ lymphocytes count.

1998

Human immunodeficiency virus (HIV) infection is associated with oxidative stress as it has been demonstrated in adult-seropositive individuals. We show in this study that serum malondialdehyde (MDA) concentration of HIV-infected children was significantly higher than in control children. A negative correlation (r = -0.515) was found in HIV-infected children between their CD4+ lymphocyte count, and MDA concentration but not with serum antioxidant status. The increase of MDA concentration in HIV-seropositive children confirms the involvement of oxidative stress in the pathophysiology of this infection also in childhood. Because of the importance of oxidative stress and antioxidants for HIV vi…

MaleAntioxidantHiv seropositivemedicine.medical_treatmentLymphocyteClinical BiochemistryBiologymedicine.disease_causeBiochemistrychemistry.chemical_compoundReference ValuesHIV SeronegativityMalondialdehydeHIV SeropositivitymedicineAdjuvant therapyHumansChildGeneral MedicineMalondialdehydePathophysiologyCD4 Lymphocyte CountOxidative Stressmedicine.anatomical_structurechemistryViral replicationChild PreschoolImmunologyMolecular MedicineRegression AnalysisFemaleOxidative stressBiomarkersBioFactors (Oxford, England)
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